HOME | 研究内容 | 原著論文 1996-2000年

27) Site-directed Mutagenesis of Human Prostacyclin Synthase: Alteration of Cys441 of the Cys- pocket, and Glu347 and Arg350 of the EXXR Motif. T. Hatae, S. Hara, C. Yokoyama, T. Yabuki, H. Inoue V. Ullrich, T. Tanabe FEBS Lett. 389, 268-272 (1996)

28) Human Gene Encoding Prostacyclin Synthase (PTGIS): Genomic Organization, Chromosomal Localization, and Promoter Activity. C. Yokoyama, T. Yabuki, H. Inoue, Y. Tone, S. Hara, T. Hatae, M Nagata, E. Takahashi, T. Tanabe Genomics 36, 296-304 (1996)

29) The Regional Distribution and Cellular Localization of mRNA Encoding Rat Prostacyclin Synthase. Y. Tone, H. Inoue, S. Hara, C. Yokoyama, T. Hatae, H. Oida, S. Narumiya, R. Shigemoto, S. Yukawa, T. Tanabe Eur. J. Cell Biol.72, 268-277 (1996)

30) Transcriptional Regulation of Human Prostaglandin-Endoperoxide Synthase-2 Gene in Vascular Endothelial Cells. H. Inoue, T. Tanabe Adv. Exp. Med. Biol. 407, 139-144 (1997)

31) Retinoids suppress phorbol estel-mediated induction of cyclooxygenase-2 J. R. Mestre, K. Subbaramaiah, P. G. Sacks, S. P. Schantz, T. Tanabe, H. Inoue, A. J. Dannenberg Cancer Res. 57, 1081-1085 (1997)  → Link

32) Benzo[a]pyrene up-regulates cyclooxygenase-2 gene expression in oral epithelial cells D. J. Kelley, J. R. Mesre, K. Subbaramaiah, P. G. Sacks, S. P. Schantz, T. Tanabe, H. Inoue, J. T. Ramonetti, A. J. Dannenberg Carcinogenesis 18, 795-799 (1997)  → Link

33) Inverse Gene Expression of Prostacyclin and Thromboxane Synthases in Resident and Activated Peritoneal Macrophages. S. Kuwamoto, H. Inoue, Y. Tone, Y. Izumi, T. Tanabe FEBS Lett. 409, 242-246 (1997)

34) Retinoids suppress epidermal growth factor-induced transcription of cyclooxygenase-2 in human oral squamous carcinoma cells. Mestre JR, Subbaramaiah K, Sacks PG, Schantz SP, Tanabe T, Inoue H, Dannenberg AJ Cancer Res. 57, 2890-2895 (1997)  → Link

35) Transcriptional Role of the Nuclear Factor B Site in the Induction by Lipopolysaccharide and Suppression by Dexamethasone of Cyclooxygenase-2 in U937 Cells. H. Inoue, T. Tanabe Biochem. Biophys. Res. Commun. 244, 143-148 (1998)

36) Cloning and expression of the gene for a vanadium-dependent bromoperoxidase from a marine macro-agla, Corallina pilulifera. M. Shimonishi, S. Kuwamoto, H. Inoue, R. Wever, T. Ohshiro, Y. Izumi, T. Tanabe FEBS Lett. 428, 105-110 (1998)

37) Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. K. Subbaramaiah, W.J. Chung, P. Michaluart, N. Telang, T. Tanabe, H. Inoue, M. Jang, J.M. Pezzuto, A.J. Dannenberg J. Biol. Chem. 273, 21875-21882 (1998)  → Link

38) Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats. S. Takahashi, J. Shigeta, H. Inoue, T. Tanabe, S. Okabe Am. J. Phys. 275, G1137-1145 (1998)  → Link

39) Cyclooxygenase expression in bovine aortic endothelial cells exposed to cyclic strain. H. Kito, C. Yokoyama, H. Inoue, T. Tanabe, N. Nakajima, B. Sumpio Endothelium 6, 107-112 (1998)

40) Glucocorticoid-mediated suppression of the promoter activity of cyclooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells. H. Inoue, K. Umesono, T. Nishimori, Y. Hirata, T. Tanabe Biochem. Biophys. Res. Commun. 254, 292-298 (1999)

41) Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenase 1 and 2 in human colon carcinoma cells. T. Kinoshita, Y. Takahashi, T. Sakashita, H. Inoue, T. Tanabe, T. Yoshimoto Biochim. Biopys. Acta 1438, 120-130 (1999)

42) Regulation of Cyclooxygenase-2 by Interferon gamma and Transforming Growth Factor alpha in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells. Role of mitogen-activated protein kinases. H. Matsuura, M, Sakaue, K. Subbaramaiah, H. Kamitani, T. E. Eling, A. J. Dannenberg, T. Tanabe, H. Inoue, J. Arata, A. M. Jetten J. Biol. Chem. 274, 29138-29148 (1999)  → Link

43) Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or -2. Y. Takahashi, F. Kawahara , M. Noguchi, K. Miwa, H. Sato, M. Seiki, H. Inoue, T. Tanabe, T. Yoshimoto FEBS Lett. 460, 145-148 (1999)

44) Feedback Control of COX-2 Expression through PPAR. H. Inoue, T. Tanabe, K. Umesono J. Biol. Chem. 275, 28028-28032 (2000)  → Link

45) 15-Deoxy-delta 12, 14 prostaglandin J2 induces G1 arrest and differentiation marker expression in vascular smooth muscle cells. Y. Miwa, T. Sasaguri, Y. Taba, M., H. Inoue, T. Abumiya Mol. Pharm. 58, 837-844 (2000)  → Link

46) Regulation of Constitutive Cyclooxygenase-2 Expression in Colon Carcinoma Cells. J. Shao, H. Sheng, H. Inoue, J. D. Morrow, R. N. DuBois J. Biol. Chem. 275, 33951-33956 (2000)  → Link